Cyclodextrine Screening for the Chiral Separation of Beta-blocker Derivatives
نویسندگان
چکیده
DANIELA LUCIA MUNTEAN1, GABRIEL HANCU2*, HAJNAL KELEMEN2, AURA RUSU2, ADRIANA CIURBA3 1 University of Medicine and Pharmacy from Tîrgu Mures, Faculty of Pharmacy, Department of Analytical Chemistry and Medicine Analysis, Gh. Marinescu 38, 540139, Tîrgu Mures, Romania 2 University of Medicine and Pharmacy from Tîrgu Mures, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Gh. Marinescu 38, 540139, Tîrgu Mures, Romania 3 University of Medicine and Pharmacy from Tîrgu Mures, Faculty of Pharmacy, Department of Pharmaceutical Technology, Gh. Marinescu 38, 540139, Tîrgu Mures, Romania
منابع مشابه
Cyclodextrine Screening for the Chiral Separation of Carvedilol by Capillary Electrophoresis
Carvedilol is administered as a racemic mixture of the R(+)- and S(-)-enantiomers, although it was demonstrated that the two enantiomers exhibit different pharmacological effects and stereoselective pharmacokinetics. The aim of this study was the evaluation of several native and derivatized cyclodextrines as chiral selectors for the separation of carvedilol enantiomers. Stereoselective interact...
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Carvedilol is administered as a racemic mixture of the R(+)- and S(-)-enantiomers, although it was demonstrated that the two enantiomers exhibit different pharmacological effects and stereoselective pharmacokinetics. The aim of this study was the evaluation of several native and derivatized cyclodextrines as chiral selectors for the separation of carvedilol enantiomers. Stereoselective interact...
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One of the problems encountered in CE separations of basic compounds is the adsorption of analytes onto the negatively charged capillary wall which could lead to poor repeatability of migration time and peak area. Additionally, separation of enantiomers of chiral of basic drugs is commonly carried out in low pH buffer which contributes to strong ionic interaction of the cationic drug ions with ...
متن کاملImprovement of Capillary Electrophoretic Enantioseparation of Fluoxetine by a Cationic Additive
One of the problems encountered in CE separations of basic compounds is the adsorption of analytes onto the negatively charged capillary wall which could lead to poor repeatability of migration time and peak area. Additionally, separation of enantiomers of chiral of basic drugs is commonly carried out in low pH buffer which contributes to strong ionic interaction of the cationic drug ions with ...
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